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http://purl.uniprot.org/citations/11426511http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11426511http://www.w3.org/2000/01/rdf-schema#comment"

Background

It has been proposed that the catechol-o-methyl transferase gene (COMT) may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Whereas studies in a North American population showed that the low activity (L) allele of a functional polymorphism in COMT was associated with OCD in male patients, this result was not supported by studies in a Japanese population. The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa.

Methods

Fifty-four unrelated OCD patients and fifty-four sex-matched controls were recruited from the same Afrikaner community. Patients and controls were phenotyped (DSM-IV) and genotyped for a NlaIII polymorphism with H (high activity) or L (low activity) alleles in the COMT gene.

Results

The H/L genotype was significantly more common than expected in the OCD patient group (P = 0.0017).

Limitations

Replication studies with related individuals may be useful in discovering factors underpinning the H/L genotype abundance in the Afrikaner population.

Conclusions

These results emphasise the need for further studies in genetically homogeneous populations to help define the complex etiology of this disease."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.org/dc/terms/identifier"doi:10.1016/s0165-0327(00)00246-9"xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Niehaus D.J."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Knowles J.A."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Brink P.A."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Corfield V.A."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Moolman-Smook J.C."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Seedat S."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Emsley R.A."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Kinnear C.J."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Potgieter A."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Stein D.J."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"Weyers J.B."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"du Toit P.L."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/author"van Kradenburg J."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/name"J Affect Disord"xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/pages"61-65"xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/title"Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population."xsd:string
http://purl.uniprot.org/citations/11426511http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/11426511http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11426511
http://purl.uniprot.org/citations/11426511http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11426511
http://purl.uniprot.org/uniprot/#_A0A140VJG8-mappedCitation-11426511http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11426511
http://purl.uniprot.org/uniprot/#_A0A4D6GI41-mappedCitation-11426511http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11426511
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