| http://purl.uniprot.org/citations/11427721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11427721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11427721 | http://www.w3.org/2000/01/rdf-schema#comment | "The daily rhythm in melatonin levels is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC ). Results presented here describe a regulatory/binding sequence in AANAT that encodes a cAMP-operated binding switch through which cAMP-regulated protein kinase-catalyzed phosphorylation [RRHTLPAN --> RRHpTLPAN] promotes formation of a complex with 14-3-3 proteins. Formation of this AANAT/14-3-3 complex enhances melatonin production by shielding AANAT from dephosphorylation and/or proteolysis and by decreasing the K(m) for 5-hydroxytryptamine (serotonin). Similar switches could play a role in cAMP signal transduction in other biological systems."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.141118798"xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.141118798"xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Beauverger P."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Beauverger P."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Boutin J.A."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Boutin J.A."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Coon S.L."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Coon S.L."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Ferry G."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Ferry G."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Ganguly S."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Ganguly S."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Gastel J.A."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Gastel J.A."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Hickman A.B."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Hickman A.B."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Jaffe H."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Jaffe H."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Klein D.C."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Klein D.C."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Namboodiri M.A."xsd:string |
| http://purl.uniprot.org/citations/11427721 | http://purl.uniprot.org/core/author | "Namboodiri M.A."xsd:string |