| http://purl.uniprot.org/citations/11427728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11427728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11427728 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ser/Thr kinase Raf-1 is a protooncogene product that is a central component in many signaling pathways involved in normal cell growth and oncogenic transformation. Upon activation, Raf-1 phosphorylates mitogen-activated protein kinase kinase (MEK), which in turn activates mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERKs), leading to the propagation of signals. Depending on specific stimuli and cellular environment, the Raf-1--MEK--ERK cascade regulates diverse cellular processes such as proliferation, differentiation, and apoptosis. Here, we describe a MEK--ERK-independent prosurvival function of Raf-1. We found that Raf-1 interacts with the proapoptotic, stress-activated protein kinase ASK1 (apoptosis signal-regulating kinase 1) in vitro and in vivo. Deletion analysis localized the Raf-1 binding site to the N-terminal regulatory fragment of ASK1. This interaction allows Raf-1 to act independently of the MEK--ERK pathway to inhibit apoptosis. Furthermore, catalytically inactive forms of Raf-1 can mimic the wild-type effect, raising the possibility of a kinase-independent function of Raf-1. Thus, Raf-1 may promote cell survival through its protein-protein interactions in addition to its established MEK kinase function."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.141224398"xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.141224398"xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Fujii K."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Fujii K."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Roberts T."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/author | "Roberts T."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/pages | "7783-7788"xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/pages | "7783-7788"xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/title | "Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/title | "Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/11427728 | http://purl.uniprot.org/core/volume | "98"xsd:string |