| http://purl.uniprot.org/citations/11431473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11431473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11431473 | http://www.w3.org/2000/01/rdf-schema#comment | "A previously unidentified Rho GTPase-activating protein (GAP) domain-containing protein was found in a yeast two-hybrid screen for cDNAs encoding proteins binding to the Src homology 3 domain of Cdc42-interacting protein 4 (CIP4). The protein was named RICH-1 (RhoGAP interacting with CIP4 homologues), and, in addition to the RhoGAP domain, it contained an N-terminal domain with endophilin homology and a C-terminal proline-rich domain. Transient transfections of RICH-1 indicated that it bound to CIP4 in vivo, as shown by co-immunoprecipitation experiments, as well as co-localization assays. In vitro assays demonstrated that the RhoGAP domain of RICH-1 catalyzed GTP hydrolysis on Cdc42 and Rac1, but not on RhoA. Ectopic expression of the RhoGAP domain as well as the full-length protein interfered with platelet-derived growth factor BB-induced membrane ruffling, but not with serum-induced stress fiber formation, further emphasizing the notion that, in vivo, RICH-1 is a GAP for Cdc42 and Rac1."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m103540200"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m103540200"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/author | "Aspenstroem P."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/author | "Aspenstroem P."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/author | "Richnau N."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/author | "Richnau N."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/pages | "35060-35070"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/pages | "35060-35070"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/title | "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/title | "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1."xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11431473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11431473 |
| http://purl.uniprot.org/citations/11431473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11431473 |
| http://purl.uniprot.org/citations/11431473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11431473 |
| http://purl.uniprot.org/citations/11431473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11431473 |
| http://purl.uniprot.org/uniprot/Q68EM7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11431473 |
| http://purl.uniprot.org/uniprot/Q15642 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11431473 |