| http://purl.uniprot.org/citations/11431695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11431695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11431695 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital malformations in humans (1/1,000 births) that result from failure of the neural tube to close during embryogenesis. The etiology of NTDs is complex, with both genetic and environmental contributions; the genetic component has been extensively studied with mouse models. Loop-tail (Lp) is a semidominant mutation on mouse chromosome 1 (ref. 4). In the two known Lp alleles (Lp, Lpm1Jus), heterozygous mice exhibit a characteristic looped tail, and homozygous embryos show a completely open neural tube in the hindbrain and spinal region, a condition similar to the severe craniorachischisis defect in humans. Morphological and neural patterning studies indicate a role for the Lp gene product in controlling early morphogenesis and patterning of both axial midline structures and the developing neural plate. The 0.6-cM/0.7-megabase (Mb) Lp interval is delineated proximally by D1Mit113/Apoa2/Fcer1g and distally by Fcer1a/D1Mit149/Spna1 and contains a minimum of 17 transcription units. One of these genes, Ltap, encodes a homolog of Drosophila Strabismus/Van Gogh (Stbm/Vang), a component of the frizzled/dishevelled tissue polarity pathway. Ltap is expressed broadly in the neuroectoderm throughout early neurogenesis and is altered in two independent Lp alleles, identifying this gene as a strong candidate for Lp."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.org/dc/terms/identifier | "doi:10.1038/90081"xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.org/dc/terms/identifier | "doi:10.1038/90081"xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Justice M.J."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Justice M.J."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Underhill D.A."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Underhill D.A."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Kibar Z."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Kibar Z."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Groulx N."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Groulx N."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Vogan K.J."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/author | "Vogan K.J."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/pages | "251-255"xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/pages | "251-255"xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/title | "Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant loop-tail."xsd:string |
| http://purl.uniprot.org/citations/11431695 | http://purl.uniprot.org/core/title | "Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant loop-tail."xsd:string |