| http://purl.uniprot.org/citations/11431696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11431696 | http://www.w3.org/2000/01/rdf-schema#comment | "During visual excitation, rhodopsin undergoes photoactivation and bleaches to opsin and all-trans-retinal. To regenerate rhodopsin and maintain normal visual sensitivity, the all-trans isomer must be metabolized and reisomerized to produce the chromophore 11-cis-retinal in biochemical steps that constitute the visual cycle and involve the retinal pigment epithelium (RPE; refs. 3-8). A key step in the visual cycle is isomerization of an all-trans retinoid to 11-cis-retinol in the RPE (refs. 9-11). It could be that the retinochrome-like opsins, peropsin, or the retinal G protein-coupled receptor (RGR) opsin12-16 are isomerases in the RPE. In contrast to visual pigments, RGR is bound predominantly to endogenous all-trans-retinal, and irradiation of RGR in vitro results in stereospecific conversion of the bound all-trans isomer to 11-cis-retinal. Here we show that RGR is involved in the formation of 11-cis-retinal in mice and functions in a light-dependent pathway of the rod visual cycle. Mutations in the human gene encoding RGR are associated with retinitis pigmentosa."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.org/dc/terms/identifier | "doi:10.1038/90089"xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Shen D."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Hao W."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Wang X.P."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Fong H.K."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Ogden T."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Rife L."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/author | "Van Boemel G.B."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/pages | "256-260"xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/title | "A photic visual cycle of rhodopsin regeneration is dependent on Rgr."xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/11431696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11431696 |
| http://purl.uniprot.org/citations/11431696 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11431696 |
| http://purl.uniprot.org/uniprot/#_A0A286YDT4-mappedCitation-11431696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11431696 |
| http://purl.uniprot.org/uniprot/#_A0A286YCJ0-mappedCitation-11431696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11431696 |
| http://purl.uniprot.org/uniprot/#_A0A286YCJ5-mappedCitation-11431696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11431696 |
| http://purl.uniprot.org/uniprot/#_Q3UEX9-mappedCitation-11431696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11431696 |