| http://purl.uniprot.org/citations/11433297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11433297 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11433297 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of expression of neural cell-adhesion molecule (N-CAM) is implicated in the progression of tumour metastasis. Here we show that N-CAM modulates neurite outgrowth and matrix adhesion of beta-cells from pancreatic tumours by assembling a fibroblast-growth-factor receptor-4 (FGFR-4) signalling complex, which consists of N-cadherin, FGFR-4, phospholipase C gamma (PLC-gamma), the adaptor protein FRS2, pp60(c-src), cortactin and growth-associated protein-43 (GAP-43). Dominant-negative FGFR-4, inhibitors of FGFR signalling and anti-beta(1)-integrin antibodies repress matrix adhesion induced by N-CAM. FGF ligands can replace N-CAM in promoting matrix adhesion but not neurite outgrowth. The results indicate that N-CAM stimulates beta1-integrin-mediated cell-matrix adhesion by activating FGFR signalling. This is a potential mechanism for preventing the dissemination of metastatic tumour cells."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.org/dc/terms/identifier | "doi:10.1038/35083041"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.org/dc/terms/identifier | "doi:10.1038/35083041"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Christofori G."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Christofori G."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Cavallaro U."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Cavallaro U."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Fuxa M."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Fuxa M."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Niedermeyer J."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/author | "Niedermeyer J."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/pages | "650-657"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/pages | "650-657"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/title | "N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/title | "N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling."xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/11433297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11433297 |
| http://purl.uniprot.org/citations/11433297 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11433297 |