| http://purl.uniprot.org/citations/11434974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11434974 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin (5-HT) uptake sites, or transporters, were measured in the neostriatum (caudate putamen) of wild type (+/+) mice and heterozygous (wv/+) and homozygous (wv/wv) weaver, as well as in heterozygous Lurcher (Lc/+) mutants. These topological surveys were carried out by quantitative ligand binding autoradiography using the uptake site antagonist [3H]-citalopram as a probe of innervation densities in four quadrants of the rostral neostriatum and in two halves of the caudal neostriatum. In addition, tissue concentrations of 5-HT, 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol were measured by high-performance liquid chromatography with electrochemical detection in these neostriatal divisions. In +/+ mice and in Lc/+ mutants there was a dorso-ventral gradient of increasing 5-HT levels, and they exhibited a similar heterogeneity of [3H]-citalopram labeling. In contrast, the gradients of 5-HT concentrations and [3H]-citalopram binding disappeared in the weaver mutants, suggesting a rearrangement of the 5-HT innervation. This reorganization of the 5-HT system in the neostriatum was more obvious in the wv/wv and is compatible with the hypothesis that the postnatal dopaminergic deficiencies that characterize weaver mutants lead to a sprouting of fibers and thus constitute a genetic model of dopaminergic denervation that leads to a 5-HT hyperinnervation."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0197-0186(01)00031-6"xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/author | "Ase A.R."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/author | "Reader T.A."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/author | "Hebert C."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/author | "Le Marec N."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/name | "Neurochem Int"xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/pages | "169-177"xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/title | "Distribution of serotonin, its metabolites and 5-HT transporters in the neostriatum of Lurcher and weaver mutant mice."xsd:string |
| http://purl.uniprot.org/citations/11434974 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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