| http://purl.uniprot.org/citations/11435439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11435439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11435439 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectins constitute a family of proteins that bind to beta-galactoside residues and have diverse physiological functions. Here we report on the identification of a galectin-like molecule, galectin-12, in a human adipose tissue cDNA library. The protein contained two potential carbohydrate-recognition domains with the second carbohydrate-recognition domain being less conserved compared with other galectins. In vitro translated galectin-12 bound to a lactosyl-agarose column far less efficiently than galectin-8. Galectin-12 mRNA was predominantly expressed in adipose tissue of human and mouse and in differentiated 3T3-L1 adipocytes. Caloric restriction and treatment of obese animals with troglitazone increased galectin-12 mRNA levels and decreased the average size of the cells in adipose tissue. The induction of galectin-12 expression by the thiazolidinedione, troglitazone, was paralleled by an increase in the number of apoptotic cells in adipose tissue. Immunocytochemical analysis revealed that galectin-12 was localized in the nucleus of adipocytes, and transfection with galectin-12 cDNA induced apoptosis of COS-1 cells. These results suggest that galectin-12, an adipose-expressed galectin-like molecule, may participate in the apoptosis of adipocytes."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m105097200"xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m105097200"xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Funahashi T."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Funahashi T."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Hotta K."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Hotta K."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsuzawa Y."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsuzawa Y."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kishida K."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kishida K."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kihara S."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kihara S."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kuriyama H."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Kuriyama H."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsukawa Y."xsd:string |
| http://purl.uniprot.org/citations/11435439 | http://purl.uniprot.org/core/author | "Matsukawa Y."xsd:string |