| http://purl.uniprot.org/citations/11440997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11440997 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, photoaffinity labeling experiments with mouse cell extracts suggested that PARP-1 functions as a surveillance protein for a stalled BER intermediate. To further understand the role of PARP-1 in BER, we examined the DNA synthesis and flap excision steps in long patch BER using a reconstituted system containing a 34-base pair BER substrate and five purified human enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap endonuclease-1 (FEN-1), and PARP-1. PARP-1 stimulates strand displacement DNA synthesis by DNA polymerase beta in this system; this stimulation is dependent on the presence of FEN-1. PARP-1 and FEN-1, therefore, cooperate to activate long patch BER. The results are discussed in the context of a model for BER sub-pathway choice, illustrating a dual role for PARP-1 as a surveillance protein for a stalled BER intermediate and an activating factor for long patch BER DNA synthesis."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100292200"xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Yang X.P."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Prasad R."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Wilson S.H."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Kedar P."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Lavrik O.I."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/author | "Vande Berg B.J."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/pages | "32411-32414"xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/title | "DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis."xsd:string |
| http://purl.uniprot.org/citations/11440997 | http://purl.uniprot.org/core/volume | "276"xsd:string |
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