| http://purl.uniprot.org/citations/11441146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11441146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11441146 | http://www.w3.org/2000/01/rdf-schema#comment | "Clock:BMAL1 and NPAS2:BMAL1 are heterodimeric transcription factors that control gene expression as a function of the light-dark cycle. Although built to fluctuate at or near a 24-hour cycle, the clock can be entrained by light, activity, or food. Here we show that the DNA-binding activity of the Clock:BMAL1 and NPAS2:BMAL1 heterodimers is regulated by the redox state of nicotinamide adenine dinucleotide (NAD) cofactors in a purified system. The reduced forms of the redox cofactors, NAD(H) and NADP(H), strongly enhance DNA binding of the Clock:BMAL1 and NPAS2:BMAL1 heterodimers, whereas the oxidized forms inhibit. These observations raise the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1060698"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1060698"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "McKnight S.L."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "McKnight S.L."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Rutter J."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Rutter J."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Wu L.C."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Wu L.C."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Reick M."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/author | "Reick M."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/pages | "510-514"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/pages | "510-514"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/title | "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/title | "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors."xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11441146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11441146 |
| http://purl.uniprot.org/citations/11441146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11441146 |