| http://purl.uniprot.org/citations/11443198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11443198 | http://www.w3.org/2000/01/rdf-schema#comment | "In view of the fact that insulin resistance is associated with atherogenesis and that troglitazone, an insulin sensitizer, has anti-inflammatory effects, which may be potentially antiatherogenic in the long term, we have now investigated whether insulin has potential anti-inflammatory effects. We infused 2.0 to 2.5 IU/h in 5% dextrose (100 mL/h) iv into 10 obese subjects for 4 h followed by 5% dextrose alone for 2 h. The rate of insulin infusion was varied to maintain glucose concentrations as close to the baseline as possible. Blood samples were obtained before and at 2, 4, and 6 h. Subjects were also infused with 5% dextrose without insulin and with saline on separate occasions. Intranuclear nuclear factor kappaB (NFkappaB) in mononuclear cells fell at 2 and further at 4 h, reverting toward the baseline at 6 h (P < 0.05). IkappaB increased significantly at 2 h, increasing further at 4 h and remaining elevated at 6 h (P < 0.001). Reactive oxygen species (ROS) generation by mononuclear cells fell significantly at 2 h and fell further at 4 h; it partially reverted to baseline at 6 h (P < 0.005). p47(phox) subunit, the key protein of nicotinamide adenine dinucleotide phosphate oxidase also fell at 2 h and 4 h, reverting toward the baseline at 6 h (P < 0.05). In addition, soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1) fell significantly following insulin infusion. Glucose or saline infusions without insulin caused no alteration in NFkappaB, IkappaB, ROS generation, p47(phox) subunit, sICAM-1, MCP-1, or PAI-1. We conclude that insulin has a potent acute anti-inflammatory effect including a reduction in intranuclear NFkappaB, an increase in IkappaB, and decreases in ROS generation, p47(phox) subunit, plasma soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1. This acute anti-inflammatory effect, if demonstrated in the long term, may have implications for atherosclerosis and its complications."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.org/dc/terms/identifier | "doi:10.1210/jcem.86.7.7623"xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Ahmad S."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Ghanim H."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Mohanty P."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Aljada A."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Assian E."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Dandona P."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/author | "Hamouda W."xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/pages | "3257-3265"xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/title | "Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?"xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/11443198 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11443198 |
| http://purl.uniprot.org/citations/11443198 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11443198 |
| http://purl.uniprot.org/uniprot/P01308#attribution-AA33F6902BB3BA2B9154024F9F212AFB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11443198 |