| http://purl.uniprot.org/citations/11448987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11448987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11448987 | http://www.w3.org/2000/01/rdf-schema#comment | "The formation of the active spliceosome, its recruitment to active areas of transcription, and its role in pre-mRNA splicing depends on the association of a number of multifunctional serine/arginine-rich (SR) proteins. ZNF265 is an arginine/serine-rich (RS) domain containing zinc finger protein with conserved pre-mRNA splicing protein motifs. Here we show that ZNF265 immunoprecipitates from splicing extracts in association with mRNA, and that it is able to alter splicing patterns of Tra2-beta1 transcripts in a dose-dependent manner in HEK 293 cells. Yeast two-hybrid analysis and immunoprecipitation indicated interaction of ZNF265 with the essential splicing factor proteins U1-70K and U2AF(35). Confocal microscopy demonstrated colocalization of ZNF265 with the motor neuron gene product SMN, the snRNP protein U1-70K, the SR protein SC35, and with the transcriptosomal components p300 and YY1. Transfection of HT-1080 cells with ZNF265-EGFP fusion constructs showed that nuclear localization of ZNF265 required the RS domain. Alignment with other RS domain-containing proteins revealed a high degree of SR dipeptide conservation. These data show that ZNF265 functions as a novel component of the mRNA processing machinery."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200010059"xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200010059"xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Rasko J.E.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Rasko J.E.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "van der Weyden L."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "van der Weyden L."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Morris B.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Morris B.J."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Mayeda A."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/author | "Mayeda A."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/pages | "25-32"xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/pages | "25-32"xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/title | "ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/11448987 | http://purl.uniprot.org/core/title | "ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."xsd:string |