| http://purl.uniprot.org/citations/11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11448989 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage. PARP-1-deficient mice are hypersensitive to genotoxic agents and display genomic instability due to a DNA repair defect in the base excision repair pathway. A previous report suggested that PARP-1-deficient mice also had a severe telomeric dysfunction consisting of telomere shortening and increased end-to-end fusions (d'Adda di Fagagna, F., M.P. Hande, W.-M. Tong, P.M. Lansdorp, Z.-Q. Wang, and S.P. Jackson. 1999. NAT: Genet. 23:76-80). In contrast to that, and using a panoply of techniques, including quantitative telomeric (Q)-FISH, we did not find significant differences in telomere length between wild-type and PARP-1(-/)-littermate mice or PARP-1(-/)-primary cells. Similarly, there were no differences in the length of the G-strand overhang. Q-FISH and spectral karyotyping analyses of primary PARP-1(-/)-cells showed a frequency of 2 end-to-end fusions per 100 metaphases, much lower than that described previously (d'Adda di Fagagna et al., 1999). This low frequency of end-to-end fusions in PARP-1(-/)-primary cells is accordant with the absence of severe proliferative defects in PARP-1(-/)-mice. The results presented here indicate that PARP-1 does not play a major role in regulating telomere length or in telomeric end capping, and the chromosomal instability of PARP-1(-/)-primary cells can be explained by the repair defect associated to PARP-1 deficiency. Finally, no interaction between PARP-1 and the telomerase reverse transcriptase subunit, Tert, was found using the two-hybrid assay."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200103049"xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Blasco M.A."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Gonzalez-Suarez E."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Menissier-de Murcia J."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "de Murcia G."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Cigudosa J.C."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Samper E."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/author | "Goytisolo F.A."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/pages | "49-60"xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/title | "Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability."xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/11448989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11448989 |
| http://purl.uniprot.org/citations/11448989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11448989 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX0-mappedCitation-11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11448989 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11448989 |
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| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11448989 |
| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11448989 |
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| http://purl.uniprot.org/uniprot/#_Q3UJ03-mappedCitation-11448989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11448989 |