| http://purl.uniprot.org/citations/11459829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11459829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11459829 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the isolation and cloning of the Wrch-1 (Wnt-1 responsive Cdc42 homolog) cDNA. Wrch-1 is a novel gene whose mRNA level increases in response to Wnt-1 signaling in Wnt-1 transformed cells, Wnt-1 transgene induced mouse mammary tumors, and Wnt-1 retrovirus infected cells. Wrch-1 encodes a homolog of the Rho family of GTPases. It shares 57% amino acid sequence identity with Cdc42, but possesses a unique N-terminal domain that contains several putative PXXP SH3-binding motifs. Like Cdc42, Wrch-1 can activate PAK-1 and JNK-1, and induce filopodium formation and stress fiber dissolution. Active Wrch-1 stimulates quiescent cells to reenter the cell cycle. Moreover, overexpression of Wrch-1 phenocopies Wnt-1 in morphological transformation of mouse mammary epithelial cells. Taken together, Wrch-1 could mediate the effects of Wnt-1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.894301"xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.894301"xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Levine A.J."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Levine A.J."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Tao W."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Tao W."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Kalejta R.F."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Kalejta R.F."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Pennica D."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/author | "Pennica D."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/pages | "1796-1807"xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/pages | "1796-1807"xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/title | "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/title | "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1."xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/11459829 | http://purl.uniprot.org/core/volume | "15"xsd:string |