| http://purl.uniprot.org/citations/11461699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11461699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11461699 | http://www.w3.org/2000/01/rdf-schema#comment | "RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 and let-7 encode small temporal RNAs (stRNAs) of 22 nt that regulate stage-specific development. Here we show that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations. Further we show that dcr-1, alg-1, and alg-2 are necessary for the maturation and activity of the lin-4 and let-7 stRNAs. Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and endogenous gene regulation."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0092-8674(01)00431-7"xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00431-7"xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Baillie D.L."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Baillie D.L."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Parrish S."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Parrish S."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Conte D."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Conte D."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Fire A."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Fire A."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Pasquinelli A.E."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Pasquinelli A.E."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Grishok A."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Grishok A."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Ha I."xsd:string |
| http://purl.uniprot.org/citations/11461699 | http://purl.uniprot.org/core/author | "Ha I."xsd:string |