| http://purl.uniprot.org/citations/11463373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11463373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11463373 | http://www.w3.org/2000/01/rdf-schema#comment | "The endoderm and much of the mesoderm arise from the EMS cell in the four-cell C. elegans embryo. We report that the MED-1 and -2 GATA factors specify the entire fate of EMS, which otherwise produces two C-like mesectodermal progenitors. The meds are direct targets of the maternal SKN-1 transcription factor; however, their forced expression can direct SKN-1-independent reprogramming of non-EMS cells into mesendodermal progenitors. We find that SGG-1/GSK-3beta kinase acts both as a Wnt-dependent activator of endoderm in EMS and an apparently Wnt-independent repressor of the meds in the C lineage, indicating a dual role for this kinase in mesendoderm development. Our results suggest that a broad tissue territory, mesendoderm, in vertebrates has been confined to a single cell in nematodes through a common gene regulatory network."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00195-2"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00195-2"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.org/dc/terms/identifier | "doi:10.1016/S1097-2765(01)00195-2"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Meneghini M.D."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Meneghini M.D."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Bowerman B."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Rothman J.H."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Rothman J.H."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Broitman-Maduro G."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Broitman-Maduro G."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Maduro M.F."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/author | "Maduro M.F."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/pages | "475-485"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/pages | "475-485"xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/title | "Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/title | "Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/11463373 | http://purl.uniprot.org/core/volume | "7"xsd:string |