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| http://purl.uniprot.org/citations/11463627 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously concluded that the Kv2.1 K(+) channel inactivates preferentially from partially activated closed states. We report here that the Kv3.1 channel also exhibits two key features of this inactivation mechanism: a U-shaped voltage dependence measured at 10 s and stronger inactivation with repetitive pulses than with a single long depolarization. More surprisingly, slow inactivation of the Kv1 Shaker K(+) channel (Shaker B Delta 6--46) also has a U-shaped voltage dependence for 10-s depolarizations. The time and voltage dependence of recovery from inactivation reveals two distinct components for Shaker. Strong depolarizations favor inactivation that is reduced by K(o)(+) or by partial block by TEA(o), as previously reported for slow inactivation of Shaker. However, depolarizations near 0 mV favor inactivation that recovers rapidly, with strong voltage dependence (as for Kv2.1 and 3.1). The fraction of channels that recover rapidly is increased in TEA(o) or high K(o)(+). We introduce the term U-type inactivation for the mechanism that is dominant in Kv2.1 and Kv3.1. U-type inactivation also makes a major but previously unrecognized contribution to slow inactivation of Shaker."xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-3495(01)75743-8"xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/author | "Klemic K.G."xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/author | "Jones S.W."xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/author | "Kirsch G.E."xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/pages | "814-826"xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/title | "U-type inactivation of Kv3.1 and Shaker potassium channels."xsd:string |
| http://purl.uniprot.org/citations/11463627 | http://purl.uniprot.org/core/volume | "81"xsd:string |
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