| http://purl.uniprot.org/citations/11464292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11464292 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular alterations in tumour cells leading to resistance towards apoptosis induced by CD95 and TRAIL-receptors are not fully understood. We report here that the stimulation of the CD95- and TRAIL-resistant human pancreatic adenocarcinoma cell line PancTuI with an agonistic anti-CD95 antibody or TRAIL resulted in activation of protein kinase C and NF-kappaB. Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished activation of NF-kappaB by anti-CD95 and TRAIL. Similarly, inhibition of NF-kappaB by MG132 or by transient transfection with a dominant negative mutant of IkappaBalpha restored the responsiveness of PancTuI cells to both death ligands. In the CD95 and TRAIL-sensitive cell line Colo357 the induction of protein kinase C and NF-kappaB following activation of CD95 and TRAIL-R was very moderate compared with PancTuI cells. However, pre-incubation of these cells with PMA strongly reduced their apoptotic response to anti-CD95 and TRAIL. Taken together, we show that activation of protein kinase C operates directly in a death receptor-dependent manner in PancTuI cells and protect pancreatic tumour cells from anti-CD95 and TRAIL-mediated apoptosis by preventing the loss DeltaPsim and Cytochrome c release as well as by induction of NF-kappaB."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204559"xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Schutze S."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Roder C."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Walczak H."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Schafer H."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Heinrich M."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Kalthoff H."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Arlt A."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Trauzold A."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Lampe E."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Oestern S."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Ungefroren H."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/author | "Wermann H."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/pages | "4258-4269"xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/title | "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11464292 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11464292 |
| http://purl.uniprot.org/citations/11464292 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11464292 |
| http://purl.uniprot.org/uniprot/O14763#attribution-14CE2672CB992DDB9408AFAC87F45575 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11464292 |
| http://purl.uniprot.org/uniprot/O00220#attribution-14CE2672CB992DDB9408AFAC87F45575 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11464292 |