| http://purl.uniprot.org/citations/11466363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11466363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11466363 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-1 is of utmost importance in the host response to immunological challenges. We identified and functionally characterized two novel IL-1 ligands termed IL-1delta and IL-1epsilon. Northern blot analyses show that these IL-1s are highly abundant in embryonic tissue and tissues containing epithelial cells (i.e., skin, lung, and stomach). In extension, quantitative real-time PCR revealed that of human skin-derived cells, only keratinocytes but not fibroblasts, endothelial cells, or melanocytes express IL-1delta and epsilon. Levels of keratinocyte IL-1delta are approximately 10-fold higher than those of IL-1epsilon. In vitro stimulation of keratinocytes with IL-1beta/TNF-alpha significantly up-regulates the expression of IL-1epsilon mRNA, and to a lesser extent of IL-1delta mRNA. In NF-kappaB-luciferase reporter assays, we demonstrated that IL-1delta and epsilon proteins do not initiate a functional response via classical IL-1R pairs, which confer responsiveness to IL-1alpha and beta or IL-18. However, IL-1epsilon activates NF-kappaB through the orphan IL-1R-related protein 2 (IL-1Rrp2), whereas IL-1delta, which shows striking homology to IL-1 receptor antagonist, specifically and potently inhibits this IL-1epsilon response. In lesional psoriasis skin, characterized by chronic cutaneous inflammation, the mRNA expression of both IL-1 ligands as well as IL-1Rrp2 are increased relative to normal healthy skin. In total, IL-1delta and epsilon and IL-1Rrp2 may constitute an independent signaling system, analogous to IL-1alphabeta/receptor agonist and IL-1R1, that is present in epithelial barriers of our body and takes part in local inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.3.1440"xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.3.1440"xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Bazan J.F."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Edwards G."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Edwards G."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Wagner J."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Wagner J."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Homey B."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Homey B."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Zurawski S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Zurawski S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Clifford T."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Clifford T."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Kastelein R.A."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Kastelein R.A."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Lo S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Lo S."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Debets R."xsd:string |
| http://purl.uniprot.org/citations/11466363 | http://purl.uniprot.org/core/author | "Debets R."xsd:string |