| http://purl.uniprot.org/citations/11476906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11476906 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock proteins (HSP) are thought to play a role in the immune response making probable their contribution to celiac disease (CD). We studied the polymorphisms in the 5' regulatory region of the HSP70-1 gene and performed genomic HLA-DQ and -DR typing in 128 CD patients and 94 healthy controls from Navarra (Spain). The frequency of the C allele of the HSP70-1, characterized by the intermediate electrophoretic mobility of DNA, was significantly increased among CD patients (64.5% vs 37.2%. p <1 x 10(-7)). When subjects were stratified by the HLA II genotype, differences were statistically significant between DR3-negative or DR3-DQB1*02-negative CD patients and matched controls. Homozygosity for the DQB1*02 allele was present in 48.4% of CD patients and 12.8% of controls (OR = 6.4; CI:3.1 to 13.8; p <1 x 10(-7)). Similar increased risk was observed for DQB1*02/*02, DRB1*03/-, or DRB1*03/07 patients. Furthermore, those individuals expressing the classical HLA alleles in CD (DQB1*02/*02, DRB1*03/*07) who also carried the HSP70-1 CC genotype were twelve times more likely to develop the disease than the matched controls. We therefore conclude that although HSP70-1 gene does not seem to be primarily associated with CD, it might be a component of the high risk haplotype, playing a role as an additional predisposing gene for the disease."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0198-8859(01)00277-4"xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Ramos-Arroyo M.A."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Sanchez-Valverde F."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Feijoo E."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Aranburu E."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Irisarri N."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Olivera J.E."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/author | "Valiente A."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/pages | "821-825"xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/title | "Heat-shock protein 70-1 and HLA class II gene polymorphisms associated with celiac disease susceptibility in Navarra (Spain)."xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/11476906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11476906 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-11476906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11476906 |