| http://purl.uniprot.org/citations/11479595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11479595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11479595 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, dosage compensation of X-linked genes is achieved by the transcriptional silencing of one X chromosome in the female (reviewed in ref. 1). This process, called X inactivation, is usually random in the embryo proper. In marsupials and the extra-embryonic region of the mouse, however, X inactivation is imprinted: the paternal X chromosome is preferentially inactivated whereas the maternal X is always active. Having more than one active X chromosome is deleterious to extra-embryonic development in the mouse. Here we show that the gene eed (embryonic ectoderm development), a member of the mouse Polycomb group (Pc-G) of genes, is required for primary and secondary trophoblast giant cell development in female embryos. Results from mice carrying a paternally inherited X-linked green fluorescent protein (GFP) transgene implicate eed in the stable maintenance of imprinted X inactivation in extra-embryonic tissues. Based on the recent finding that the Eed protein interacts with histone deacetylases, we suggest that this maintenance activity involves hypoacetylation of the inactivated paternal X chromosome in the extra-embryonic tissues."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng574"xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng574"xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Schneider E."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Schneider E."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Nagy A."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Nagy A."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Cross J.C."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Cross J.C."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Mager J."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/author | "Mager J."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/pages | "371-375"xsd:string |
| http://purl.uniprot.org/citations/11479595 | http://purl.uniprot.org/core/pages | "371-375"xsd:string |