| http://purl.uniprot.org/citations/11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11482129 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the role of HLA-DQA1 genotypes and their interaction with HLA-DRB1 in the pathogenesis of rheumatoid arthritis (RA) in Taiwan, HLA-DQA1 was determined in 71 patients with RA and 108 healthy controls by SSP-PCR method. HLA-DRB1 and HLA-DQA1 were simultaneously detected in 55 RA patients and 101 healthy controls. PCR/SSOP method was used to determine the HLA-DRB1 genotypes, and the subtypes of HLA-DR4 were determined by cloning and sequencing. The phenotypic frequency of HLA-DQA1*0301 was significantly lower in RA than in controls, and, in contrast, the HLA-DQA1*0302 and DQA1*0303 were significantly higher in RA than in controls. The associations of DQA1*0301, *0302, and *0303 with RA were independent of DR4 and DRB1*0405. Moreover, the interactions between HLA-DR4 and HLA-DQA1*0302 or DQA1*0303 could enhance the development of RA. We also found that the prevalence of bone erosion and seropositivity of rheumatoid factor (RF) were significantly higher in HLA-DQA1*0303 positive RA patients than in healthy controls. HLA-DQA1*0302 and DQA1*0303 are the risk factors for susceptibility to RA, while HLA-DQA1*0301 is a protective factor. A synergistic effect for the susceptibility to RA can be found between HLA-DR4 and HLA-DQA1*0302 or DQA1*0303. We also found that the HLA-DQA1*0303 was related to bone erosion and seropositivity of RF in RA patients."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Lin S.C."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Liu H.W."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Tsai W.C."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Yen J.H."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/author | "Ou T.T."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/name | "Kaohsiung J Med Sci"xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/pages | "183-189"xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/title | "HLA-DQA1 genotyping in patients with rheumatoid arthritis in Taiwan."xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/11482129 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11482129 |
| http://purl.uniprot.org/citations/11482129 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |
| http://purl.uniprot.org/uniprot/#_A0A141R7F8-mappedCitation-11482129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11482129 |