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http://purl.uniprot.org/citations/11489943http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11489943http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11489943http://www.w3.org/2000/01/rdf-schema#comment"In humans, natural killer (NK) cell function is regulated by a series of receptors and coreceptors with either triggering or inhibitory activity. Here we describe a novel 60-kD glycoprotein, termed NTB-A, that is expressed by all human NK, T, and B lymphocytes. Monoclonal antibody (mAb)-mediated cross-linking of NTB-A results in the induction of NK-mediated cytotoxicity. Similar to 2B4 (CD244) functioning as a coreceptor in the NK cell activation, NTB-A also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that also NTB-A may function as a coreceptor in the process of NK cell activation. Molecular cloning of the cDNA coding for NTB-A molecule revealed a novel member of the immunoglobulin superfamily belonging to the CD2 subfamily. NTB-A is characterized, in its extracellular portion, by a distal V-type and a proximal C2-type domain and by a cytoplasmic portion containing three tyrosine-based motifs. NTB-A undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease (XLP) showed that the lack of SH2D1A protein profoundly affects the function not only of 2B4 but also of NTB-A. Thus, in XLP-NK cells, NTB-A mediates inhibitory rather than activating signals. These inhibitory signals are induced by the interaction of NTB-A with still undefined ligands expressed on Epstein-Barr virus (EBV)-infected target cells. Moreover, mAb-mediated masking of NTB-A can partially revert this inhibitory effect while a maximal recovery of target cell lysis can be obtained when both 2B4 and NTB-A are simultaneously masked. Thus, the altered function of NTB-A appears to play an important role in the inability of XLP-NK cells to kill EBV-infected target cells."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.org/dc/terms/identifier"doi:10.1084/jem.194.3.235"xsd:string
http://purl.uniprot.org/citations/11489943http://purl.org/dc/terms/identifier"doi:10.1084/jem.194.3.235"xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Notarangelo L.D."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Notarangelo L.D."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Bottino C."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Bottino C."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Falco M."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Falco M."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Moretta L."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Moretta L."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Parolini S."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Parolini S."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Augugliaro R."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Augugliaro R."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Biassoni R."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Biassoni R."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Moretta A."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Moretta A."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Marcenaro E."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Marcenaro E."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Sivori S."xsd:string
http://purl.uniprot.org/citations/11489943http://purl.uniprot.org/core/author"Sivori S."xsd:string
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