| http://purl.uniprot.org/citations/11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11489982 | http://www.w3.org/2000/01/rdf-schema#comment | "When naive CD4 T cells are primed, they rapidly differentiate into polarized Th1 and/or Th2 phenotypes. A major factor in producing such polarization is the early production of cytokines (IL-12 and IFN-gamma in the case of Th1 cells and IL-4 in the case of Th2 cells). One issue that remains unresolved is the source of the early IFN-gamma that synergizes with IL-12 to fully polarize CD4 T cells into Th1 cells. We have examined this question by injecting mice with anti-CD3 and examining cells from normal and various MHC-knockout mice. We found that IFN-gamma is induced rapidly in a small subset of CD8 T cells. This subset is absent in mice that lack beta2-microglobulin, but not in K(b)D(b)-double-knockout mice, indicating that these CD8 T cells are dependent on nonclassical MHC class Ib molecules. The early burst of IFN-gamma polarizes CD4 T cells toward Th1 cells, in part by stimulating the release of IL-12 from APC. We also use TAP- and CD1-knockout mice to show that such cells are not CD1-restricted NK T cells, nor are they dependent on TAP-1 transport for surface expression of the relevant MHC class Ib molecule. Therefore, they arise on MHC class Ib molecules that do not depend on TAP-1 transporters."xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.4.2004"xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/author | "Das G."xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/author | "Janeway C.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/author | "Sheridan S."xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/pages | "2004-2010"xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/title | "The source of early IFN-gamma that plays a role in Th1 priming."xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11489982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11489982 |
| http://purl.uniprot.org/citations/11489982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J090-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
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| http://purl.uniprot.org/uniprot/#_A0A494BAT0-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-11489982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11489982 |