| http://purl.uniprot.org/citations/11500040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11500040 | http://www.w3.org/2000/01/rdf-schema#comment | "Bloom Syndrome (BS) is a human autosomal genetic disorder characterized by a predisposition to a variety of malignant tumors. The gene responsible for BS encodes a protein (BLM) consisting of 1417 amino acids with a nuclear localization signal in the C-terminal region, which is a member of the RecQ helicase family. We previously showed, using a yeast two-hybrid system, that BLM interacted with Ubc9, which is the conjugating enzyme of SUMO-1 (small ubiquitin-related modifier-1). In the present study, we exogenously expressed a green fluorescent protein-tagged Bloom syndrome protein, GFP-BLM, in human 293EBNA cells and found that it formed dots/rod-like structures associated with SUMO-1 in the nucleus. Deletion experiments indicated that the region from amino acids 238 to 586 of BLM is required for the formation of dots/rod-like structures associated with SUMO-1, and the DNA helicase domain, but not the helicase activity itself, slightly affected the formation and/or stability of these structures. Expression of a GFP-BLM which contained the 238-586 region, but lacked the C-terminal nuclear localization signal, resulted in localization to the cytoplasm without the formation of dots/rod-like structures and association with SUMO-1, indicating that these events occur only in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.5387"xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Seki M."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Kondo N."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Mizuno S."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Harata M."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Enomoto T."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Kaneko H."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Masuko T."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/author | "Kawabe Yi"xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/pages | "322-327"xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/title | "The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1."xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/11500040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11500040 |
| http://purl.uniprot.org/citations/11500040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11500040 |
| http://purl.uniprot.org/uniprot/P54132#attribution-41A1BA6ACB36881ADDEF418A14BF19A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11500040 |