| http://purl.uniprot.org/citations/11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11500376 | http://www.w3.org/2000/01/rdf-schema#comment | "Disruption of Dictyostelium rasC, encoding a Ras subfamily protein, generated cells incapable of aggregation. While rasC expression is enriched in a cell type-specific manner during post-aggregative development, the defect in rasC(-) cells is restricted to aggregation and fully corrected by application of exogenous cAMP pulses. cAMP is not produced in rasC(-) cells stimulated by 2'-deoxy-cAMP, but is produced in response to GTPgammaS in cell lysates, indicating that G-protein-coupled cAMP receptor activation of adenylyl cyclase is regulated by RasC. However, cAMP-induced ERK2 phosphorylation is unaffected in rasC(-) cells, indicating that RasC is not an upstream activator of the mitogen-activated protein kinase required for cAMP relay. rasC(-) cells also exhibit reduced chemotaxis to cAMP during early development and delayed response to periodic cAMP stimuli produced by wild-type cells in chimeric mixtures. Furthermore, cAMP-induced Akt/PKB phosphorylation through a phosphatidylinositide 3-kinase (PI3K)-dependent pathway is dramatically reduced in rasC(-) cells, suggesting that G-protein-coupled serpentine receptor activation of PI3K is regulated by RasC. Cells lacking the RasGEF, AleA, exhibit similar defects as rasC(-) cells, suggesting that AleA may activate RasC."xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.16.4490"xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/author | "Lim C.J."xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/author | "Weeks G."xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/author | "Spiegelman G.B."xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/pages | "4490-4499"xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/title | "RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation."xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11500376 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11500376 |
| http://purl.uniprot.org/citations/11500376 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11500376 |
| http://purl.uniprot.org/uniprot/Q54PQ4#attribution-3922B5B23002D677B29461474B617258 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/Q8IS21#attribution-3922B5B23002D677B29461474B617258 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/P32253#attribution-3922B5B23002D677B29461474B617258 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P13773-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P32253-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_Q54PQ4-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_Q54QB1-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P03967-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P16051-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P54644-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_P54673-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |
| http://purl.uniprot.org/uniprot/#_Q03100-mappedCitation-11500376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11500376 |