| http://purl.uniprot.org/citations/11502588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11502588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11502588 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated and characterized the human homolog of the rat largest urea transporter of the UT-A family (hUT-A1). The 4.2-kb hUT-A1 cDNA encodes a 920-amino acid peptide, which is 89% identical to the rat UT-A1 protein. By Northern hybridization, hUT-A1 expression is detected in the human inner medulla as a approximately 4.4-kb mRNA transcript. By Western analysis, hUT-A1 is identified as a approximately 100-kDa protein in the human inner medulla. By immunohistochemistry, hUT-A1 expression is localized to the inner medullary collecting duct (IMCD). When transfected into HEK-293 cells hUT-A1 cDNA is translated into a approximately 98-kDa protein. Expression of hUT-A1 in Xenopus oocytes results in phloretin-inhibitable uptake of (14)C-urea, which shows only modest stimulation by cAMP, suggesting that in the human IMCD vasopressin may have a limited role in the short-term regulation of hUT-A1-mediated urea transport. We determined the organization of the human Slc14a2 gene and identified 20 exons distributed over approximately 67.5 kb on chromosome 18, from which hUT-A1 and the other human urea transporter, hUT-A2, are transcribed."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.2001.281.3.f400"xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.2001.281.3.f400"xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Peng T."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Peng T."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Janech M.G."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Janech M.G."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Sands J.M."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Sands J.M."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Bagnasco S.M."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Bagnasco S.M."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Karakashian A."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/author | "Karakashian A."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/pages | "F400-F406"xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/pages | "F400-F406"xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/title | "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/title | "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene."xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/11502588 | http://purl.uniprot.org/core/volume | "281"xsd:string |