| http://purl.uniprot.org/citations/11504942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11504942 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor-1alpha (HIF-1alpha) is a global transcriptional regulator of the hypoxic response. Under normoxic conditions, HIF-1alpha is recognized by the von Hippel-Lindau tumor-suppressor protein (VHL), a component of an E3 ubiquitin ligase complex. This interaction thereby promotes the rapid degradation of HIF-1alpha. Under hypoxic conditions, HIF-1alpha is stabilized. We have previously shown that VHL binds in a hypoxia-sensitive manner to a 27-aa segment of HIF-1alpha, and that this regulation depends on a posttranslational modification of HIF-1alpha. Through a combination of in vivo coimmunoprecipitation assays using VHL and a panel of point mutants of HIF-1alpha in this region, as well as MS and in vitro binding assays, we now provide evidence that this modification, which occurs under normoxic conditions, is hydroxylation of Pro-564 of HIF-1alpha. The data furthermore show that this proline hydroxylation is the primary regulator of VHL binding."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.181341498"xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/author | "Yu F."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/author | "Lee F.S."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/author | "White S.B."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/pages | "9630-9635"xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/title | "HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation."xsd:string |
| http://purl.uniprot.org/citations/11504942 | http://purl.uniprot.org/core/volume | "98"xsd:string |
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