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| http://purl.uniprot.org/citations/11513152 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been identified, the immunoglobulin-like family (killer cell immunoglobulin-like receptors (KIRs), leukocyte immunoglobulin-like receptors (LIRs)) and the C-type lectin-like family (Ly49, CD94/NKG2A, NKG2D, CD69). Recently, the three-dimensional structures of several NK receptors were determined, in free form or bound to MHC-I. These include those of unbound KIRs, NKG2D, CD69, LIR-1 and the CD94 subunit of the CD94/NKG2A heterodimer. Together, these structures define the basic molecular architecture of both the immunoglobulin-like and C-type lectin-like families of NK receptors. In addition, crystal structures have been reported for the complex between Ly49A and H-2Dd, and for KIR2DL2 bound to HLA-Cw3. The complex structures provide a framework for understanding MHC-I recognition by NK receptors from both families and reveal striking differences in the nature of this recognition, despite the receptors' functional similarity."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1600-065x.2001.1810104.x"xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Natarajan K."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Mariuzza R.A."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Margulies D.H."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Sawicki M.W."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/author | "Dimasi N."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/name | "Immunol Rev"xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/pages | "52-65"xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/title | "Structural basis of MHC class I recognition by natural killer cell receptors."xsd:string |
| http://purl.uniprot.org/citations/11513152 | http://purl.uniprot.org/core/volume | "181"xsd:string |
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