| http://purl.uniprot.org/citations/11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11516655 | http://www.w3.org/2000/01/rdf-schema#comment | "The anterior-posterior axis of C. elegans is defined by the asymmetric division of the one-cell zygote, and this is controlled by the PAR proteins, including PAR-3 and PAR-6, which form a complex at the anterior of the cell, and PAR-1, which localizes at the posterior [1-4]. PAR-1 plays a similar role in axis formation in Drosophila: the protein localizes to the posterior of the oocyte and is necessary for the localization of the posterior and germline determinants [5, 6]. PAR-1 has recently been shown to have an earlier function in oogenesis, where it is required for the maintenance of oocyte fate and the posterior localization of oocyte-specific markers [7, 8]. Here, we show that the homologs of PAR-3 (Bazooka) and PAR-6 are also required to maintain oocyte fate. Germline clones of mutants in either gene give rise to egg chambers that develop 16 nurse cells and no oocyte. Furthermore, oocyte-specific factors, such as Orb protein and the centrosomes, still localize to one cell but fail to move from the anterior to the posterior cortex. Thus, PAR-1, Bazooka, and PAR-6 are required for the earliest polarity in the oocyte, providing the first example in Drosophila where the three homologs function in the same process. Although these PAR proteins therefore seem to play a conserved role in early anterior-posterior polarity in C. elegans and Drosophila, the relationships between them are different, as the localization of PAR-1 does not require Bazooka or PAR-6 in Drosophila, as it does in the worm."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(01)00244-5"xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/author | "Knoblich J.A."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/author | "St Johnston D."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/author | "Petronczki M."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/author | "Huynh J.R."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/pages | "901-906"xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/title | "Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/11516655 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11516655 |
| http://purl.uniprot.org/citations/11516655 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11516655 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS3-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_A1ZBL5-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_A1ZBL7-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_A1ZBL9-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_E1JGK6-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_E1JGM9-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_E1JGN0-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_O44224-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_O45116-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_O96782-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |
| http://purl.uniprot.org/uniprot/#_O97111-mappedCitation-11516655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11516655 |