| http://purl.uniprot.org/citations/11526399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11526399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11526399 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. Although some cellular responses are completely abolished in MyD88-deficient mice, TLR4, but not TLR9, can activate NF-kappa B and mitogen-activated protein kinases and induce dendritic cell maturation in the absence of MyD88. These differences suggest that another adapter must exist that can mediate MyD88-independent signaling in response to TLR4 ligation. We have identified and characterized a Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) and have shown that it controls activation of MyD88-independent signaling pathways downstream of TLR4. We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni0901-835"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni0901-835"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Horng T."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Horng T."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Barton G.M."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/author | "Barton G.M."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/pages | "835-841"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/pages | "835-841"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/title | "TIRAP: an adapter molecule in the Toll signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/title | "TIRAP: an adapter molecule in the Toll signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/11526399 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11526399 |
| http://purl.uniprot.org/citations/11526399 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11526399 |
| http://purl.uniprot.org/citations/11526399 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11526399 |
| http://purl.uniprot.org/citations/11526399 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11526399 |