| http://purl.uniprot.org/citations/11527966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11527966 | http://www.w3.org/2000/01/rdf-schema#comment | "The gene KCNQ1 encodes a K(+) channel alpha-subunit important for cardiac repolarization, formerly known as K(v)LQT1. In large and small intestine a channel complex consisting of KCNQ1 and the beta-subunit KCNE3 (MiRP2) is known to mediate the cAMP-activated basolateral K(+) current, which is essential for luminal Cl(-) secretion. Northern blot experiments revealed an expression of both subunits in lung tissue. However, previous reports suggested a role of KCNE1 (minK, Isk) but not KCNE3 in airway epithelial cells. Here we give evidence that KCNE1 is not detected in murine tracheal epithelial cells and that Cl(-) secretion by these cells is not reduced by the knock-out of the KCNE1 gene. In contrast we show that a complex consisting of KCNQ1 and KCNE3 probably forms a basolateral K(+) channel in murine tracheal epithelial cells. As described for colonic epithelium, the current through KCNQ1 complexes in murine trachea is specifically inhibited by the chromanol 293B. A 293B-sensitive current was present after stimulation with forskolin and agonists that increase Ca(2+) as well as after administration of the pharmacological K(+) channel activator, 1-EBIO. A 293B-inhibitable current was already present under control conditions and reduced after administration of amiloride indicating a role of this K(+) channel not only for Cl(-) secretion but also for Na(+) reabsorption. We conclude that at least in mice a KCNQ1 channel complex seems to be the dominant basolateral K(+) conductance in tracheal epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m105014200"xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/author | "Grahammer F."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/author | "Warth R."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/author | "Bleich M."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/author | "Barhanin J."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/author | "Hug M.J."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/pages | "42268-42275"xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/title | "The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea."xsd:string |
| http://purl.uniprot.org/citations/11527966 | http://purl.uniprot.org/core/volume | "276"xsd:string |
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