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http://purl.uniprot.org/citations/11527997http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11527997http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11527997http://www.w3.org/2000/01/rdf-schema#comment"We purified two new minidefensins (RTD-2 and RTD-3) from the bone marrow of rhesus monkeys. Both were circular octadecapeptides that contained three intramolecular disulfide bonds and were homologous to RTD-1, a circular (theta) defensin previously described by Tang et al. (Science, 286, 498-502, 1999). However, whereas the 18 residues of RTD-1 represent spliced nonapeptide fragments derived from two different demidefensin precursors, RTD-2 and -3 comprise tandem nonapeptide repeats derived from only one of the RTD-1 precursors. Thus, circular minidefensins are products of a novel posttranslational system that generates effector molecule diversity without commensurate genome expansion. A system wherein two demidefensin genes can produce three circular minidefensins might allow n such genes to produce (n/2)(n+1) peptides."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Nguyen T."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Nguyen T."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Hong T."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Hong T."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Zhao C."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Zhao C."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Waring A.J."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Waring A.J."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Lehrer R.I."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Lehrer R.I."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Kokryakov V.N."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Kokryakov V.N."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Aleshina G."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Aleshina G."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Leonova L."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/author"Leonova L."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/name"J. Leukoc. Biol."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/name"J. Leukoc. Biol."xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/pages"461-464"xsd:string
http://purl.uniprot.org/citations/11527997http://purl.uniprot.org/core/pages"461-464"xsd:string