| http://purl.uniprot.org/citations/11533490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11533490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11533490 | http://www.w3.org/2000/01/rdf-schema#comment | "Natriuretic peptides (NPs) are vasoactive cyclic-peptide hormones important in blood pressure regulation through interaction with natriuretic cell-surface receptors. We report the hormone-binding thermodynamics and crystal structures at 2.9 and 2.0 angstroms, respectively, of the extracellular domain of the unliganded human NP receptor (NPR-C) and its complex with CNP, a 22-amino acid NP. A single CNP molecule is bound in the interface of an NPR-C dimer, resulting in asymmetric interactions between the hormone and the symmetrically related receptors. Hormone binding induces a 20 angstrom closure between the membrane-proximal domains of the dimer. In each monomer, the opening of an interdomain cleft, which is tethered together by a linker peptide acting as a molecular spring, is likely a conserved allosteric trigger for intracellular signaling by the natriuretic receptor family."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1062246"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1062246"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "He X.-L."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "He X.-L."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Chow D.-C."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Chow D.-C."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Martick M.M."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/author | "Martick M.M."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/pages | "1657-1662"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/pages | "1657-1662"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/title | "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/title | "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone."xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11533490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11533490 |
| http://purl.uniprot.org/citations/11533490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11533490 |