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| http://purl.uniprot.org/citations/11533666 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear lamins are intermediate filaments that compose the nuclear lamina--the filamentous meshwork underlying the inner nuclear membrane--and are required for nuclear assembly, organization and maintenance. Here we present evidence that a nuclear lamin is also required for cytoplasmic organization in two highly polarized cell types. Zygotic loss-of-function mutations in the Drosophila gene encoding the principal lamin (Dm(0)) disrupt the directed outgrowth of cytoplasmic extensions from terminal cells of the tracheal system. Germline mutant clones disrupt dorsal-ventral polarity of the oocyte. In mutant oocytes, transcripts of the dorsal determinant Gurken, a transforming growth factor-alpha homologue, fail to localize properly around the anterodorsal surface of the oocyte nucleus; their ventral spread results in dorsalized eggs that resemble those of the classical dorsalizing mutations squid and fs(1)K10. The requirement of a nuclear lamin for cytoplasmic as well as nuclear organization has important implications for both the cellular functions of lamins and the pathogenesis of human diseases caused by lamin mutations."xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb0901-848"xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/author | "Guillemin K."xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/author | "Williams T."xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/author | "Krasnow M.A."xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/pages | "848-851"xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/title | "A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/11533666 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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