| http://purl.uniprot.org/citations/11536016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11536016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11536016 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here the identification and functional characterization of two new human caspase recruitment domain (CARD) molecules, termed Pseudo-interleukin-1beta converting enzyme (ICE) and ICEBERG. Both proteins share a high degree of homology, reaching 92% and 53% identity, respectively, to the prodomain of caspase-1/ICE. Interestingly, both Pseudo-ICE and ICEBERG are mapped to chromosome 11q22 that bears caspases-1, -4- and -5 genes, all involved in cytokine production rather than in apoptosis. We demonstrate that Pseudo-ICE and ICEBERG interact physically with caspase-1 and block, in a monocytic cell line, the interferon-gamma and lipopolysaccharide-induced secretion of interleukin-1beta which is a well-known consequence of caspase-1 activation. Moreover, Pseudo-ICE, but not ICEBERG, interacts with the CARD-containing kinase RICK/RIP2/CARDIAK and activates NF-kappaB. Our data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of IL-1beta secretion and NF-kappaB activation during the pro-inflammatory cytokine response."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4400881"xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4400881"xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Druilhe A."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Druilhe A."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Ahmad M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Ahmad M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Razmara M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/author | "Razmara M."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/name | "Cell Death Differ."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/pages | "649-657"xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/pages | "649-657"xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/title | "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/title | "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins."xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11536016 | http://purl.uniprot.org/core/volume | "8"xsd:string |