| http://purl.uniprot.org/citations/11544529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11544529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11544529 | http://www.w3.org/2000/01/rdf-schema#comment | "The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, with TLR-4 mediating the response to lipopolysaccharide from Gram-negative bacteria. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signalling; however, our understanding of how TLR-4 signals is incomplete. Here we describe a protein, Mal (MyD88-adapter-like), which joins MyD88 as a cytoplasmic TIR-domain-containing protein in the human genome. Mal activates NF-kappaB, Jun amino-terminal kinase and extracellular signal-regulated kinase-1 and -2. Mal can form homodimers and can also form heterodimers with MyD88. Activation of NF-kappaB by Mal requires IRAK-2, but not IRAK, whereas MyD88 requires both IRAKs. Mal associates with IRAK-2 by means of its TIR domain. A dominant negative form of Mal inhibits NF-kappaB, which is activated by TLR-4 or lipopolysaccharide, but it does not inhibit NF-kappaB activation by IL-1RI or IL-18R. Mal associates with TLR-4. Mal is therefore an adapter in TLR-4 signal transduction."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.org/dc/terms/identifier | "doi:10.1038/35092578"xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.org/dc/terms/identifier | "doi:10.1038/35092578"xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Gray P."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Gray P."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Bowie A.G."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Bowie A.G."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Harte M.T."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Harte M.T."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Smith D.E."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Smith D.E."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Brady G."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Brady G."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Bird T.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Bird T.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Jefferies C.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "Jefferies C.A."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "O'Neill L.A.J."xsd:string |
| http://purl.uniprot.org/citations/11544529 | http://purl.uniprot.org/core/author | "O'Neill L.A.J."xsd:string |