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http://purl.uniprot.org/citations/11546872http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11546872http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11546872http://www.w3.org/2000/01/rdf-schema#comment"Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.org/dc/terms/identifier"doi:10.1126/science.1062257"xsd:string
http://purl.uniprot.org/citations/11546872http://purl.org/dc/terms/identifier"doi:10.1126/science.1062257"xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Huang D.C.S."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Huang D.C.S."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Strasser A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Strasser A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Villunger A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Villunger A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Beaumont J.G."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Beaumont J.G."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Puthalakath H."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Puthalakath H."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"O'Reilly L.A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"O'Reilly L.A."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Cheney R.E."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Cheney R.E."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Coultas L."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/author"Coultas L."xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/11546872http://purl.uniprot.org/core/name"Science"xsd:string