| http://purl.uniprot.org/citations/11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11550085 | http://www.w3.org/2000/01/rdf-schema#comment | "In contrast to the autoprocessing of caspase-9, little is known about the biological significance of caspase-9 processing by caspase-3 via a feedback loop in vivo. We prepared antisera against mouse caspase-9 cleavage sites so that only the activated form of mouse caspase-9 was recognized. Using these antisera and caspase-9- and caspase-3-deficient mouse embryonic fibroblasts, we demonstrated that mouse caspase-9 is initially autoprocessed at D(353) and D(368) at low levels during staurosporine-induced apoptosis, whereupon the D(368) and D(168) sites are preferentially processed over D(353) by activated caspase-3 as part of a feedback amplification loop. Ac-DEVD-MCA (caspase-3-like) and Ac-LEHD-MCA (caspase-9-like) cleavage activities clearly showed that caspase-9 autoprocessing was necessary for the activation of caspase-3, whereas full activation of caspase-3 and caspase-9 was achieved only through the feedback amplification loop. This feedback amplification loop also played a predominant role during programmed cell death of dorsal root ganglia neurons at mouse embryonic day 11.5."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4400824"xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/author | "Momoi T."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/author | "Fujita E."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/author | "Urase K."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/author | "Kuida K."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/author | "Egashira J."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/pages | "335-344"xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/title | "Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo."xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11550085 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11550085 |
| http://purl.uniprot.org/citations/11550085 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11550085 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_A2AS92-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_A2AS93-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q8BNT4-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q4FJK5-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q3TRE1-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q8C3Q0-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q8C3Q9-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |
| http://purl.uniprot.org/uniprot/#_Q9R0S9-mappedCitation-11550085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11550085 |