| http://purl.uniprot.org/citations/11551227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11551227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11551227 | http://www.w3.org/2000/01/rdf-schema#comment | "Syntrophins have been proposed to serve as adapter proteins. Syntrophins are found in the dystrophin glycoprotein complex (DGC); defects in the constituents of this complex are linked to various muscular dystrophies. Blot overlay experiments demonstrate that alpha-dystroglycan, beta-dystroglycan, and syntrophins all bind Grb2, the growth factor receptor bound adapter protein. Mouse alpha1-syntrophin sequences were produced as chimeric fusion proteins in bacteria and found to also bind Grb2 in a Ca2+-independent manner. This binding was localized to the proline rich sequences adjacent to and overlapping with the N-terminal pleckstrin homology domain (PH1). Grb2 bound syntrophin with an apparent KD of 563 +/-15 nM. Grb2-C-SH3 domain bound syntrophin with slightly higher affinity than Grb2-N-SH3 domain. Crk-L, an SH2/SH3 protein of similar domain structure but different specificity, does not bind these syntrophin sequences."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi010490n"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi010490n"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Petrucci T.C."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Petrucci T.C."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Jarrett H.W."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Jarrett H.W."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Oak S.A."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Oak S.A."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Russo K."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/author | "Russo K."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/pages | "11270-11278"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/pages | "11270-11278"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/title | "Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/title | "Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling."xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/11551227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11551227 |
| http://purl.uniprot.org/citations/11551227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11551227 |