| http://purl.uniprot.org/citations/11553333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11553333 | http://www.w3.org/2000/01/rdf-schema#comment | "A fundamental control point in the regulation of the initiation of protein synthesis is the formation of the eukaryotic initiation factor 4F (eIF-4F) complex. The formation of this complex depends upon the availability of the mRNA cap binding protein, eIF-4E, which is sequestered away from the translational machinery by the tight association of eIF-4E binding proteins (4E-BPs). Phosphorylation of 4E-BP1 is critical in causing its dissociation from eIF-4E, leaving 4E available to form translationally active eIF-4F complexes, switching on mRNA translation. In this report, we provide the first evidence that the phosphorylation of 4E-BP1 increases during mitosis and identify Ser-65 and Thr-70 as phosphorylated sites. Phosphorylation of Thr-70 has been implicated in the regulation of 4E-BP1 function, but the kinase phosphorylating this site was unknown. We show that the cyclin-dependent kinase, cdc2, phosphorylates 4E-BP1 at Thr-70 and that phosphorylation of this site is permissive for Ser-65 phosphorylation. Crucially, the increased phosphorylation of 4E-BP1 during mitosis results in its complete dissociation from eIF-4E."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(01)00422-5"xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/author | "Heesom K.J."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/author | "Gampel A."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/author | "Mellor H."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/author | "Denton R.M."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/pages | "1374-1379"xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/title | "Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)."xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/11553333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11553333 |
| http://purl.uniprot.org/citations/11553333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11553333 |
| http://purl.uniprot.org/uniprot/#_Q13541-mappedCitation-11553333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11553333 |
| http://purl.uniprot.org/uniprot/Q13541 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11553333 |