| http://purl.uniprot.org/citations/11567051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11567051 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine whether neurons lacking huntingtin can participate in development and survive in postnatal brain, we used two approaches in an effort to create mice consisting of wild-type cells and cells without huntingtin. In one approach, chimeras were created by aggregating the 4-8 cell embryos from matings of Hdh (+/-) mice with wild-type 4-8 cell embryos. No chimeric offspring that possessed homozygous Hdh (-/-) cells were obtained thereby, although statistical considerations suggest that such chimeras should have been created. By contrast, Hdh (-/-) ES cells injected into blastocysts yielded offspring that were born and in adulthood were found to have Hdh (-/-) neurons throughout brain. The Hdh (-/-) cells were, however, 5-10 times more common in hypothalamus, midbrain, and hindbrain than in telencephalon and thalamus. Chimeric animals tended to be smaller than wild-type littermates, and chimeric mice rich in Hdh (-/-) cells tended to show motor abnormalities. Nonetheless, no brain malformations or pathologies were evident. The apparent failure of aggregation chimeras possessing Hdh (-/-) cells to survive to birth is likely attributable to the previously demonstrated critical role of huntingtin in extraembryonic membranes. That Hdh (-/-) cells in chimeric mice created by blastocyst injection are under-represented in adult telencephalon and thalamus implies a role for huntingtin in the development of these regions, whereas the neurological dysfunction in brains enriched in Hdh (-/-) cells suggests a role for huntingtin in adult brain. Nonetheless, the lengthy survival of Hdh (-/-) cells in adult chimeric mice indicates that individual neurons in many brain regions do not require huntingtin to participate in normal brain development and to survive."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.21-19-07608.2001"xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Goldowitz D."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Reiner A."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Zeitlin S."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Dragatsis I."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Meade C.A."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/author | "Del Mar N."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/pages | "7608-7619"xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/title | "Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice."xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11567051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11567051 |
| http://purl.uniprot.org/citations/11567051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11567051 |
| http://purl.uniprot.org/uniprot/P42859#attribution-3EB3C9EBC8CC12301BF01ED0C45D3FE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11567051 |
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| http://purl.uniprot.org/uniprot/P42859 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11567051 |
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