| http://purl.uniprot.org/citations/11574675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11574675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11574675 | http://www.w3.org/2000/01/rdf-schema#comment | "PNRC2 (proline-rich nuclear receptor co-regulatory protein 2) was identified using mouse steroidogenic factor 1 (SF1) as bait in a yeast two-hybrid screening of a human mammary gland cDNA expression library. PNRC2 is an unusual coactivator in that it is the smallest coactivator identified so far, with a molecular weight of 16 kDa, and interacts with nuclear receptors using a proline-rich sequence. In yeast two-hybrid assays PNRC2 interacted with orphan receptors SF1 and estrogen receptor-related receptor alpha1 in a ligand-independent manner. PNRC2 was also found to interact with the ligand-binding domains of estrogen receptor, glucocorticoid receptor, progesterone receptor, thyroid receptor, retinoic acid receptor and retinoid X receptor in a ligand-dependent manner. A functional activation function 2 domain is required for nuclear receptors to interact with PNRC2. Using the yeast two-hybrid assay, the region amino acids 85-139 was found to be responsible for the interaction with nuclear receptors. This region contains an SH3 domain-binding motif (SEPPSPS) and an NR box-like sequence (LKTLL). A mutagenesis study has shown that the SH3 domain-binding motif is important for PNRC2 to interact with all the nuclear receptors tested. Our results reveal that PNRC2 has a structure and function similar to PNRC, a previously characterized coactivator. These two proteins represent a new type of nuclear receptor co-regulatory proteins."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.19.3939"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.19.3939"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/pages | "3939-3948"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/pages | "3939-3948"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/title | "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/title | "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/11574675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11574675 |
| http://purl.uniprot.org/citations/11574675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11574675 |
| http://purl.uniprot.org/citations/11574675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11574675 |
| http://purl.uniprot.org/citations/11574675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11574675 |
| http://purl.uniprot.org/uniprot/Q9NPJ4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11574675 |
| http://purl.uniprot.org/uniprot/Q12796 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11574675 |