| http://purl.uniprot.org/citations/11577348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11577348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11577348 | http://www.w3.org/2000/01/rdf-schema#comment | "Bruton's tyrosine kinase (Btk) is required for human and mouse B cell development. Btk deficiency causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Unlike Src proteins, Btk lacks a negative regulatory domain at the COOH terminus and may rely on cytoplasmic Btk-binding proteins to regulates its kinase activity by trans-inhibitor mechanisms. Consistent with this possibility, IBtk, which we identified as an inhibitor of Btk, bound to the PH domain of Btk. IBtk downregulated Btk kinase activity, Btk-mediated calcium mobilization and nuclear factor-kappaB-driven transcription. These results define a potential mechanism for the regulation of Btk function in B cells."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1001-939"xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1001-939"xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Nelson D.L."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Nelson D.L."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Rabin R.L."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Rabin R.L."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Palmieri C."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Palmieri C."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Quinto I."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Quinto I."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Scala G."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Scala G."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Schwartz O.M."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/author | "Schwartz O.M."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11577348 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |