| http://purl.uniprot.org/citations/11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11579093 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear export of ribonucleoprotein complexes requires cis-acting signals and recognition by receptors that mediate translocation through the nuclear pore complex. Translocation is likely to involve a series of physical interactions between the ribonucleoprotein complex and nucleoporins within the nuclear pore complex. Here, we have characterized the function of NXT1 in the context of the Tap-dependent RNA export pathway. Tap has been implicated in the nuclear export of RNA transcripts derived from Mason-Pfizer monkey virus that contain the constitutive transport element. We demonstrate that NXT1 stimulates binding of a Tap-RNA complex to nucleoporins in vitro, and we provide mutational analysis that shows these interactions are necessary for nuclear export of an intron-containing viral mRNA in vivo. Tap contains separate domains for binding to nucleoporins and NXT1, both of which are critical for its export function. RNA export is mediated by a heterodimer of Tap and NXT1, and the function of NXT1 on this pathway is to regulate the affinity of the Tap-RNA complex for nucleoporins within the nuclear pore complex. We propose that NXT1-dependent binding of the Tap-RNA complex to the nucleoporin p62, which we have reconstituted in vitro using recombinant proteins, represents a single step of the translocation reaction."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106558200"xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Guan T."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Paschal B.M."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Black B.E."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Levesque L."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Rekosh D."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Hammarskjold M.L."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Coyle J."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/author | "Guzik B."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/pages | "44953-44962"xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/title | "RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex."xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11579093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11579093 |
| http://purl.uniprot.org/citations/11579093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11579093 |
| http://purl.uniprot.org/uniprot/Q99JX7#attribution-C7A1653AFA90C6EA7FDB4562C022BCF9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/Q9QZV9#attribution-C7A1653AFA90C6EA7FDB4562C022BCF9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/#_P52948-mappedCitation-11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/#_Q07955-mappedCitation-11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ77-mappedCitation-11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/#_A0A140LJH5-mappedCitation-11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11579093 |
| http://purl.uniprot.org/uniprot/#_A8CG34-mappedCitation-11579093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11579093 |