| http://purl.uniprot.org/citations/11581258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11581258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/11581258 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae Ste24p is a multispanning membrane protein implicated in the CAAX proteolysis step that occurs during biogenesis of the prenylated a-factor mating pheromone. Whether Ste24p acts directly as a CAAX protease or indirectly to activate a downstream protease has not yet been established. In this study, we demonstrate that purified, detergent-solubilized Ste24p directly mediates CAAX proteolysis in a zinc-dependent manner. We also show that Ste24p mediates a separate proteolytic step, the first NH(2)-terminal cleavage in a-factor maturation. These results establish that Ste24p functions both as a bona fide COOH-terminal CAAX protease and as an a-factor NH(2)-terminal protease. Importantly, this study is the first to directly demonstrate that a eukaryotic multispanning membrane protein can possess intrinsic proteolytic activity."xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106150200"xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106150200"xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/author | "Tam A."xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/author | "Michaelis S."xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/author | "Schmidt W.K."xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/pages | "46798-46806"xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/title | "The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor."xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11581258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11581258 |
| http://purl.uniprot.org/citations/11581258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11581258 |
| http://purl.uniprot.org/citations/11581258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11581258 |
| http://purl.uniprot.org/citations/11581258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11581258 |
| http://purl.uniprot.org/enzyme/3.4.24.84 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11581258 |
| http://purl.uniprot.org/uniprot/P47154#attribution-9C9F2A494C1C1A37FDC875ACEB2DB711 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11581258 |
| http://purl.uniprot.org/uniprot/#_Q03530-mappedCitation-11581258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11581258 |
| http://purl.uniprot.org/uniprot/#_P47154-mappedCitation-11581258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11581258 |
| http://purl.uniprot.org/uniprot/P47154 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11581258 |
| http://purl.uniprot.org/uniprot/Q03530 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11581258 |