| http://purl.uniprot.org/citations/11583311 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11583311 | http://www.w3.org/2000/01/rdf-schema#comment | "We hypothesized that increased prothrombin levels associated with G20210A prothrombin gene mutation could affect the results of activated protein C (APC) resistance phenotype and increase the risk of venous thrombosis (VT). The increasing addition of purified prothrombin in plasma of 90 normal subjects resulted in a parallel significant increase of APC resistance. Significantly different mean n-APC-SR in 879 GG20210 subjects compared to 27 heterozygous carriers of isolated G20210A mutation was observed (1.0 +/- 0.12 vs. 0.95 +/-0.11; P = 0.02) in a random sample of 906 normal population subjects. Twenty-seven families with VT and isolated G20210A mutation consecutively diagnosed during 1998-1999 were evaluated. Mean n-APC-SR was significantly lower in the 80 G20210A carriers compared to 58 GG 20210 relatives investigated, even after sex and age adjustment (0.92 +/- 0.08 vs. 1.05 +/-0.13; P < 0.0001). A strong relationship between plasma prothrombin level and n-APC-SR was observed in the families. When n-APC-SR values were grouped in tertiles, the odds ratio for VTE, after exclusion of the index cases and adjustment for 20210 status, for subjects in the lowest tertile (n-APC-SR 0.73-0.90) was 4.58 (95% CI 0.78-26.88) compared to upper tertile (n-APC-SR 1.01-1.30). In conclusion, in subjects with G20210A mutation APC resistance is significantly increased, correlates with plasma prothrombin level and the carriers with the lowest APC resistance values have an increased risk of VTE."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Castaman G."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Rodeghiero F."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Ruggeri M."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Madeo D."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Simioni M."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/author | "Tosetto A."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/pages | "804-808"xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/title | "Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis."xsd:string |
| http://purl.uniprot.org/citations/11583311 | http://purl.uniprot.org/core/volume | "86"xsd:string |
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