| http://purl.uniprot.org/citations/11583626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11583626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11583626 | http://www.w3.org/2000/01/rdf-schema#comment | "TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a ternary complex with a Phe-Gly (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally similar to the homodimeric transport factor NTF2, but unlike NTF2, it is incompatible with either homodimerization or Ran binding. The NTF2-like heterodimer functions as a single structural unit in recognizing an FG repeat at a hydrophobic pocket present only on TAP and not on p15. This FG binding site interacts synergistically with a second site at the C terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00348-3"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00348-3"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Izaurralde E."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Conti E."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Conti E."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Fribourg S."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Fribourg S."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Braun I.C."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/author | "Braun I.C."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/pages | "645-656"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/pages | "645-656"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/title | "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/title | "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor."xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11583626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11583626 |
| http://purl.uniprot.org/citations/11583626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11583626 |