| http://purl.uniprot.org/citations/11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11585799 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila development is coordinated by pulses of the steroid hormone 20-hydroxyecdysone (20E). During metamorphosis, the 20E-inducible Broad-Complex (BR-C) gene plays a key role in the genetic hierarchies that transduce the hormone signal, being required for the destruction of larval tissues and numerous aspects of adult development. Most of the known BR-C target genes, including the salivary gland secretion protein (Sgs) genes, are terminal differentiation genes that are thought to be directly regulated by BR-C-encoded transcription factors. Here, we show that repression of Sgs expression is indirectly controlled by the BR-C through transcriptional down-regulation of fork head, a tissue-specific gene that plays a central role in salivary gland development and is required for Sgs expression. Our results demonstrate that integration of a tissue-specific regulatory gene into a 20E-controlled genetic hierarchy provides a mechanism for hormonal repression. Furthermore, they suggest that the BR-C is placed at a different position within the 20E-controlled hierarchies than previously assumed, and that at least part of its pleiotropic functions are mediated by tissue-specific regulators."xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.128.19.3729"xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/author | "Lehmann M."xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/author | "King-Jones K."xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/author | "Renault N."xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/pages | "3729-3737"xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/title | "Downregulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response."xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/11585799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11585799 |
| http://purl.uniprot.org/citations/11585799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11585799 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHC0-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_A0A126GV17-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EEH5-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_D8FT05-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_M9MSM6-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_E1JJ07-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_E1JJB2-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_P02840-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_P02841-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_P02842-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_Q3YNB8-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |
| http://purl.uniprot.org/uniprot/#_Q7K2S6-mappedCitation-11585799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11585799 |